tca cycle analysis

As the second stage of cellular respiration, TCA cycle, tricarboxylic acid cycle, also called Krebs cycle or citric acid cycle, is an important aerobic pathway for the complete oxidation of carbohydrates and fatty acids. It is a pathway widely exists all aerobic living organisms. The TCA cycle plays an important role in the metabolism of organic fuel molecules such as glucose, fatty acids, some amino acids and some other sugars. Before entering the TCA cycle, these rather large molecules must be degraded into acetyl coenzyme A (acetyl CoA), a two-carbon compound. Acetyl-CoA is the activated form of acetate. The primary sources of acetyl-CoA are pyruvate oxidation of carbohydrates, glycolysis of glucose, and beta-oxidation of fatty acids. The NADH generated in this pathway is used for the oxidative phosphorylation and other metabolism pathways. 2-oxoglutarate is one of the important precursor metabolites generated in this pathway. Carbon dioxide and ATPs are the end products of citric acid cycle. At the end of the cycle, oxaloacetate is regenerated. So, TCA cycle is a closed loop.

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