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45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
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Potassium voltage-gated channel (abbreviated as KCNA3) belongs to shaker-related subfamily of member 3. KCNA3 encodes the voltage-gated Kv1.3 channel which is expressed in T and B lymphocytes. All human T cells express roughly 300 Kv1.3 channels per cell. From a functional and structural point of view KCNA3 is the most complex voltage-gated ion channel. As a central channel with a divergent filter property consisting of a homotetramer and four transmembrane protein subunits KCNA3 channel can conduct ions which can make the potassium ions pass smoothly. There will be one or two P-loop regions on each transmembrane protein subunit. P-loop is... read more
Tel: 6316197922
Potassium voltage-gated channel (abbreviated as KCNA3) belongs to shaker-related subfamily of member 3. KCNA3 encodes the voltage-gated Kv1.3 channel which is expressed in T and B lymphocytes. All human T cells express roughly 300 Kv1.3 channels per cell. From a functional and structural point of view KCNA3 is the most complex voltage-gated ion channel. As a central channel with a divergent filter property consisting of a homotetramer and four transmembrane protein subunits KCNA3 channel can conduct ions which can make the potassium ions pass smoothly. There will be one or two P-loop regions on each transmembrane protein subunit. P-loop is... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
Melanin-concentrating hormone receptor 1 also known as MCH1 is one of the melanin-concentrating hormone receptors found in all mammals. The protein encoded by this gene a member of the G protein-coupled receptor family 1 is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors this protein does not seem to bind somatostatin.... read more
Tel: 6316197922
Melanin-concentrating hormone receptor 1 also known as MCH1 is one of the melanin-concentrating hormone receptors found in all mammals. The protein encoded by this gene a member of the G protein-coupled receptor family 1 is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors this protein does not seem to bind somatostatin.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
Lymphocyte function-associated antigen 1(LFA-1) is part of the family of leukocyte integrins that are recognised by their common β-chains (β2 CD18). It is found on all T-cells and also on B-cells macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. It is the first to bind T-cells to antigen-presenting cells and initially binds weakly.... read more
Tel: 6316197922
Lymphocyte function-associated antigen 1(LFA-1) is part of the family of leukocyte integrins that are recognised by their common β-chains (β2 CD18). It is found on all T-cells and also on B-cells macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. It is the first to bind T-cells to antigen-presenting cells and initially binds weakly.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
Lysine-specific histone demethylase 1A (KDM1A) also known as lysine (K)-specific demethylase 1A (LSD1) is a protein in humans that is encoded by the KDM1A gene.LSD1 is a flavin-dependent monoamine oxidase which can demethylate mono- and di-methylated lysines specifically histone 3 lysines 4 and 9 (H3K4 and H3K9).This enzyme can have roles critical in embryogenesis and tissue-specific differentiation as well as oocyte growth. KDM1A was the first histone demethylase to be discovered though more than 30 have been described.... read more
Tel: 6316197922
Lysine-specific histone demethylase 1A (KDM1A) also known as lysine (K)-specific demethylase 1A (LSD1) is a protein in humans that is encoded by the KDM1A gene.LSD1 is a flavin-dependent monoamine oxidase which can demethylate mono- and di-methylated lysines specifically histone 3 lysines 4 and 9 (H3K4 and H3K9).This enzyme can have roles critical in embryogenesis and tissue-specific differentiation as well as oocyte growth. KDM1A was the first histone demethylase to be discovered though more than 30 have been described.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
Researchers from industry and academia have synthesized structurally diverse LpxC inhibitors exhibiting different LpxC inhibitory and antibacterial activities. Current search for novel LpxC inhibitors is focused on small molecules sharing common structural features like a Zn2+-chelating group as well as a highly lipophilic side-chain. However despite the promising preclinical data of many of the reported compounds no other LpxC inhibitor besides the recently withdrawn clinical candidate ACHN-975 has entered clinical trials. The lack of clinical candidates might be related with undesired effects caused by the common structural elements of the LpxC inhibitors. Among the disclosed compounds the N-aroyl-L-threonine- and methylsulfone-based... read more
Tel: 6316197922
Researchers from industry and academia have synthesized structurally diverse LpxC inhibitors exhibiting different LpxC inhibitory and antibacterial activities. Current search for novel LpxC inhibitors is focused on small molecules sharing common structural features like a Zn2+-chelating group as well as a highly lipophilic side-chain. However despite the promising preclinical data of many of the reported compounds no other LpxC inhibitor besides the recently withdrawn clinical candidate ACHN-975 has entered clinical trials. The lack of clinical candidates might be related with undesired effects caused by the common structural elements of the LpxC inhibitors. Among the disclosed compounds the N-aroyl-L-threonine- and methylsulfone-based... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Leucyl-tRNA synthetase cytoplasmic is an enzyme that in humans is encoded by the LARS gene Catalog Product Name CAS Number 1234563-16-6 Epetraborole HCl 1234563-16-6... read more
Leucyl-tRNA synthetase cytoplasmic is an enzyme that in humans is encoded by the LARS gene Catalog Product Name CAS Number 1234563-16-6 Epetraborole HCl 1234563-16-6... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Lead optimization is a diversified operation in drug discovery in which the chemical structures of compounds or biologics are modified to improve target’s specificity selectivity pharmacodynamics pharmacokinetic and toxicological properties to generate preclinical drug candidates. In order to understand the need for lead optimization it is important to determine the basic characteristics of leads and in order to make a compound a drug sample at least five basic attributes need to be considered including potency bioavailability duration safety and pharmaceutical acceptability.... read more
Lead optimization is a diversified operation in drug discovery in which the chemical structures of compounds or biologics are modified to improve target’s specificity selectivity pharmacodynamics pharmacokinetic and toxicological properties to generate preclinical drug candidates. In order to understand the need for lead optimization it is important to determine the basic characteristics of leads and in order to make a compound a drug sample at least five basic attributes need to be considered including potency bioavailability duration safety and pharmaceutical acceptability.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
As an efficient method to accelerate the process of drug discovery fragment screening has been widely recognized in academic and commercial fields. The FBDD method usually first determines the affinity of a water-soluble small molecule compound (relative molecular mass... read more
As an efficient method to accelerate the process of drug discovery fragment screening has been widely recognized in academic and commercial fields. The FBDD method usually first determines the affinity of a water-soluble small molecule compound (relative molecular mass... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
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In general screening libraries contain amounts of compounds for the demands of academia and industry which is inconvenient for researchers to study in the specific areas. Activity-based libraries are designed for researchers with the classification of compounds according to their potential application in different fields of drug discovery which use combination of validated descriptors and compound properties.... read more
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In general screening libraries contain amounts of compounds for the demands of academia and industry which is inconvenient for researchers to study in the specific areas. Activity-based libraries are designed for researchers with the classification of compounds according to their potential application in different fields of drug discovery which use combination of validated descriptors and compound properties.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Chemical libraries contain a collection of diversity of real or virtual chemical compounds which offers customers a powerful guarantee for custom synthesis. These custom libraries utilize an advanced chemistry-focused proprietary technology platform which meets the most challenging quality standards of the world's leading pharmaceutical companies.... read more
Chemical libraries contain a collection of diversity of real or virtual chemical compounds which offers customers a powerful guarantee for custom synthesis. These custom libraries utilize an advanced chemistry-focused proprietary technology platform which meets the most challenging quality standards of the world's leading pharmaceutical companies.... read more
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