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45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Major types of Prostanoid Receptor E-type prostanoid (EP) receptors are an important class of prostanoid receptor termed EP1 EP2 EP3 and EP4. EP1 was the first reported EP receptor and was found in kidney and lung tissue at a low level. The human EP1 receptor is composed of 402 amino acids sharing a sequence homology of 86% with the rat EP1 receptor. EP2 and EP4 have the similarities in pharmacology and functional coupling mediating celluar signaling via adenylate cyclase activity. The EP3 receptor is reported to have various isoforms that differ in the amino acid sequence of the C-terminal region.... read more
Major types of Prostanoid Receptor E-type prostanoid (EP) receptors are an important class of prostanoid receptor termed EP1 EP2 EP3 and EP4. EP1 was the first reported EP receptor and was found in kidney and lung tissue at a low level. The human EP1 receptor is composed of 402 amino acids sharing a sequence homology of 86% with the rat EP1 receptor. EP2 and EP4 have the similarities in pharmacology and functional coupling mediating celluar signaling via adenylate cyclase activity. The EP3 receptor is reported to have various isoforms that differ in the amino acid sequence of the C-terminal region.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
An overview of Aryl hydrocarbon receptors Aryl hydrocarbon receptor belonging to the superfamily of basic helix loop helix/Per-Arnt-Sim proteins was identified as a cytosolic receptor for polycyclic aromatic hydrocarbon. Structurally the aryl hydrocarbon receptor consists of basic helix loop helix domain and Per-Arnt-Sim domain which are responsible for DNA binding and ligand binding. The sequence of aryl hydrocarbon receptor is composed of 848 amino acids and a molecular of 90 kDa. The aryl hydrocarbon receptor is expressed in vertebrate cells and plays key regulatory roles in normal physiology like immune inflammatory responses and atherogenesis. Besides aryl hydrocarbon receptor mediates function... read more
An overview of Aryl hydrocarbon receptors Aryl hydrocarbon receptor belonging to the superfamily of basic helix loop helix/Per-Arnt-Sim proteins was identified as a cytosolic receptor for polycyclic aromatic hydrocarbon. Structurally the aryl hydrocarbon receptor consists of basic helix loop helix domain and Per-Arnt-Sim domain which are responsible for DNA binding and ligand binding. The sequence of aryl hydrocarbon receptor is composed of 848 amino acids and a molecular of 90 kDa. The aryl hydrocarbon receptor is expressed in vertebrate cells and plays key regulatory roles in normal physiology like immune inflammatory responses and atherogenesis. Besides aryl hydrocarbon receptor mediates function... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Inhibition of BRPF1 There are two types of BRPF1 inhibitors reported on the basis of structures: 1 3-dimethylbenzimidazolone and N-methylquinoline-2-ketone. GSK6853 is a BRPF1 bromodomain inhibitor with high selectivity developed by GSK and other companies. The physicochemical properties of GSK6853 and good cellular activity will contribute to its cellular and in vivo studies as a chemical probe molecule for the biological functions of BRPF1 bromodomain. The N-methylquinoline-2-ketone compound NI-57 is a BRPF bromodomain inhibitor with Kd values of 31 110 and 410 nmol/L for BRPF1 BRPF2 and BRPF3 respectively. Experiments indicated that NI-57 showed an activity of submicromolar concentration on... read more
Inhibition of BRPF1 There are two types of BRPF1 inhibitors reported on the basis of structures: 1 3-dimethylbenzimidazolone and N-methylquinoline-2-ketone. GSK6853 is a BRPF1 bromodomain inhibitor with high selectivity developed by GSK and other companies. The physicochemical properties of GSK6853 and good cellular activity will contribute to its cellular and in vivo studies as a chemical probe molecule for the biological functions of BRPF1 bromodomain. The N-methylquinoline-2-ketone compound NI-57 is a BRPF bromodomain inhibitor with Kd values of 31 110 and 410 nmol/L for BRPF1 BRPF2 and BRPF3 respectively. Experiments indicated that NI-57 showed an activity of submicromolar concentration on... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Chalcones Catalog Product Name CAS Number B0005-158407 2' 4'-Dihydroxy-2 3' 6'-trimethoxychalcone 100079-39-8 1044743-35-2 3'-Methylflavokawin 1044743-35-2 3'-Methyl-4-O-methylhelichrysetin 109471-13-8 Asebotin 11075-15-3 112408-67-0 3-Deoxysappanchalcone 112408-67-0 118266-99-2 Isodorsmanin A 118266-99-2 1190225-47-8 Sarcandrone A 1190225-47-8 1190225-48-9 Sarcandrone B 1190225-48-9 Loureirin A 119425-89-7 119425-90-0 Loureirin B 119425-90-0 B0005-188552 Ethyllucidone 1195233-59-0 B0005-161896 Sulfuretin 120-05-8 120926-46-7 Isoliquiritin apioside 120926-46-7 123316-64-3 2'-O-Methylhelichrysetin 123316-64-3 129724-43-2 2' 4'-Dihydroxy-3' 6'-dimethoxychalcone 129724-43-2... read more
Chalcones Catalog Product Name CAS Number B0005-158407 2' 4'-Dihydroxy-2 3' 6'-trimethoxychalcone 100079-39-8 1044743-35-2 3'-Methylflavokawin 1044743-35-2 3'-Methyl-4-O-methylhelichrysetin 109471-13-8 Asebotin 11075-15-3 112408-67-0 3-Deoxysappanchalcone 112408-67-0 118266-99-2 Isodorsmanin A 118266-99-2 1190225-47-8 Sarcandrone A 1190225-47-8 1190225-48-9 Sarcandrone B 1190225-48-9 Loureirin A 119425-89-7 119425-90-0 Loureirin B 119425-90-0 B0005-188552 Ethyllucidone 1195233-59-0 B0005-161896 Sulfuretin 120-05-8 120926-46-7 Isoliquiritin apioside 120926-46-7 123316-64-3 2'-O-Methylhelichrysetin 123316-64-3 129724-43-2 2' 4'-Dihydroxy-3' 6'-dimethoxychalcone 129724-43-2... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Inhibition of CCKA Application of CCK-AR antagonists can offset the reduction in food intake and satiety caused by a high-fat diet. Intravenous injection of the CCKA receptor antagonist loxiglumide can significantly reduce dietary satiety and nausea and reduce the pressure during bloating. The use of the CCK-AR antagonist loxiglumide increases insulin secretion without changing the original sugar intake and eliminates all pathways for postprandial secretion of the pancreatic polypeptide. Dexloxiglumide is a right-handed body of loxiglumide. It is a potent and selective CCK1 receptor antagonist for the treatment of constipation-type irritable bowel syndrome. It is the most advanced CCK1 in... read more
Inhibition of CCKA Application of CCK-AR antagonists can offset the reduction in food intake and satiety caused by a high-fat diet. Intravenous injection of the CCKA receptor antagonist loxiglumide can significantly reduce dietary satiety and nausea and reduce the pressure during bloating. The use of the CCK-AR antagonist loxiglumide increases insulin secretion without changing the original sugar intake and eliminates all pathways for postprandial secretion of the pancreatic polypeptide. Dexloxiglumide is a right-handed body of loxiglumide. It is a potent and selective CCK1 receptor antagonist for the treatment of constipation-type irritable bowel syndrome. It is the most advanced CCK1 in... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
The Inhibition of DHODH During last decades researchers had discovered a large number of DHODH inhibitors such as leflunomide brequinar teriflunomide (A77 1726) benzimidazole and so on. Leflunomide is an approved DHODH inhibitor that has been widely used for the treatment of arthritis. As classic DHODH inhibitors leflunomide and its active metabolite A77 1726 have been demonstrated to suppress cell proliferation or to induce cell death in various tumors. Importantly DHODH inhibition by leflunomide induced a significant decrease in melanoma growth both in vitro and in vivo studies. Similarly brequinar sodium is another DHODH inhibitor that showed anti-tumour effect in... read more
Tel: 6316197922
The Inhibition of DHODH During last decades researchers had discovered a large number of DHODH inhibitors such as leflunomide brequinar teriflunomide (A77 1726) benzimidazole and so on. Leflunomide is an approved DHODH inhibitor that has been widely used for the treatment of arthritis. As classic DHODH inhibitors leflunomide and its active metabolite A77 1726 have been demonstrated to suppress cell proliferation or to induce cell death in various tumors. Importantly DHODH inhibition by leflunomide induced a significant decrease in melanoma growth both in vitro and in vivo studies. Similarly brequinar sodium is another DHODH inhibitor that showed anti-tumour effect in... read more
Unit No. 12, 1st Floor, Neminath industrial Estate No. 6, Navghar, Vasai East, Palghar-410210,Maharashtra, India., Mumbai
Tel: 2502390032
OXFORD LAB FINE CHEM LLP was established to meet the growing demand of Lab and Research Chemicals in India and worldwide countries.We are the masters in manufacturing importing and exporting of laboratory chemicals and intermediates since decades.We are one of the trusted manufacturers of more than 2000 products in different grades such as LR AR/GR HPLC Grade Laboratory Reagents & Fine Chemicals for services to industries such Pharma Chemicals Laboratories and Educational institutions processed for organic synthesis analytical testing in semi-bulk and bulk quantities.... read more
Tel: 2502390032
OXFORD LAB FINE CHEM LLP was established to meet the growing demand of Lab and Research Chemicals in India and worldwide countries.We are the masters in manufacturing importing and exporting of laboratory chemicals and intermediates since decades.We are one of the trusted manufacturers of more than 2000 products in different grades such as LR AR/GR HPLC Grade Laboratory Reagents & Fine Chemicals for services to industries such Pharma Chemicals Laboratories and Educational institutions processed for organic synthesis analytical testing in semi-bulk and bulk quantities.... read more
A-86, T.T.C. MIDC. Indl. Area, Thane-Belapur Road, Kopar Khairane, Navi Mumbai, Maharashtra, 400 705., Mumbai
Tel: 8097812209
Our firm is a full-fledged supplier of high technology custom-designed commercial irradiation facilities and systems. commercial irradiation is a relatively new concept in India. In India the general public is not aware of this concept fully. commercial irradiation ensures medical and pharmaceutical products safety and sterilization. Symec Engineers (I) Pvt. Ltd. Is an Engineering company employed in developing high technology custom-designed facilities and systems for Biotech Pharmaceutical chemical and food processing industries.... read more
Tel: 8097812209
Our firm is a full-fledged supplier of high technology custom-designed commercial irradiation facilities and systems. commercial irradiation is a relatively new concept in India. In India the general public is not aware of this concept fully. commercial irradiation ensures medical and pharmaceutical products safety and sterilization. Symec Engineers (I) Pvt. Ltd. Is an Engineering company employed in developing high technology custom-designed facilities and systems for Biotech Pharmaceutical chemical and food processing industries.... read more
Plot No.29 B, Everest Industrial Zone,, Opp.Poonam Dumper, B/H Tata Showroom,Gondal Road Highway,, Rajkot
Tel: 9510812341
We serve different types of laminated tubes like Aluminum tubes Plastic barrier tubes Printed tubes and cosmetics tubes.We serve different types of laminated tubes like Aluminum tubes Plastic barrier tubes Printed tubes and cosmetics tubes.... read more
Tel: 9510812341
We serve different types of laminated tubes like Aluminum tubes Plastic barrier tubes Printed tubes and cosmetics tubes.We serve different types of laminated tubes like Aluminum tubes Plastic barrier tubes Printed tubes and cosmetics tubes.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Plecanatide CAT#10-101-170 CAS No.467426-54-6 DescriptionPlecanatide is similar to uroguanylin and structurally related to human uroguanylin. Plecanatide acts as a guanylate cyclase-C (GC-C) agonist. Both plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium to stimulate secretion of intestinal fluid. Synonyms/Alias(3-Glutamic acid(D>E))human uroguanylin (UGN) Molecular FormulaC65H104N18O26S4 M.W/Mr.1681.88626 SequenceH-Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH Labeling TargetGuanylate cyclase-C (GC-C) ApplicationPlecanatide is used for the treatment of chronic idiopathic constipation (CIC). ActivityAgonist... read more
Plecanatide CAT#10-101-170 CAS No.467426-54-6 DescriptionPlecanatide is similar to uroguanylin and structurally related to human uroguanylin. Plecanatide acts as a guanylate cyclase-C (GC-C) agonist. Both plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium to stimulate secretion of intestinal fluid. Synonyms/Alias(3-Glutamic acid(D>E))human uroguanylin (UGN) Molecular FormulaC65H104N18O26S4 M.W/Mr.1681.88626 SequenceH-Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH Labeling TargetGuanylate cyclase-C (GC-C) ApplicationPlecanatide is used for the treatment of chronic idiopathic constipation (CIC). ActivityAgonist... read more
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