Peptide
129 RESULTS WITHIN anywhere FROM https:, United States
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
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Synthesis challenges and strategies of long peptides There are some challenges to the synthesis of long peptides such as a large cumulative effect of yield which can result in slow or incomplete coupling and/or reverse protection during the synthesis as well as low solubility in the assembly of the protected peptide. For the synthesis of long peptides there are generally two ways of gradual growth and fragment condensation. The former starts with the starting amino acid (or peptide) and grows one amino acid per connection. The latter is obtained by condensation of a C-terminal protective peptide and an N-terminal protective... read more
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Synthesis challenges and strategies of long peptides There are some challenges to the synthesis of long peptides such as a large cumulative effect of yield which can result in slow or incomplete coupling and/or reverse protection during the synthesis as well as low solubility in the assembly of the protected peptide. For the synthesis of long peptides there are generally two ways of gradual growth and fragment condensation. The former starts with the starting amino acid (or peptide) and grows one amino acid per connection. The latter is obtained by condensation of a C-terminal protective peptide and an N-terminal protective... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
Peptoids or poly-N-substituted glycines are a class of peptidomimetics whose side chains are appended to the nitrogen atom of the peptide backbone rather than to the α-carbons (as they are in amino acids). Notably peptoids lack the amide hydrogen which is responsible for many of the secondary structure elements in peptides and proteins. Peptoids were first invented by Reyna J. Simon Paul Bartlett and Daniel V. Santi to mimic protein/peptide products to aid in the discovery of protease-stable small molecule drugs. Our services Creative Peptides has developed an innovative peptoid synthesis service to meet the increasing needs in drug target... read more
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Peptoids or poly-N-substituted glycines are a class of peptidomimetics whose side chains are appended to the nitrogen atom of the peptide backbone rather than to the α-carbons (as they are in amino acids). Notably peptoids lack the amide hydrogen which is responsible for many of the secondary structure elements in peptides and proteins. Peptoids were first invented by Reyna J. Simon Paul Bartlett and Daniel V. Santi to mimic protein/peptide products to aid in the discovery of protease-stable small molecule drugs. Our services Creative Peptides has developed an innovative peptoid synthesis service to meet the increasing needs in drug target... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
Synthesis of recombinant peptide Design and construction of a expression vector Expression and purification of recombinant fused peptides Proteolytic cleavage and purification of recombinant peptides Why Choose Creative Peptides? Superior Precision: Creative Peptides’ recombinant peptide technology provides custom peptides exactly as requested. Every step of peptide synthesis is subject to Creative Peptides’ stringent quality control. Excellent Procedure: Conventional chemical peptide synthesis has only limited abilities to synthesize long or complicated peptides whereas our proprietary recombinant peptide technology can handle the toughest possible peptide sequences of any length on any scale. Scalable System: In quantities of several milligrams up to 100... read more
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Synthesis of recombinant peptide Design and construction of a expression vector Expression and purification of recombinant fused peptides Proteolytic cleavage and purification of recombinant peptides Why Choose Creative Peptides? Superior Precision: Creative Peptides’ recombinant peptide technology provides custom peptides exactly as requested. Every step of peptide synthesis is subject to Creative Peptides’ stringent quality control. Excellent Procedure: Conventional chemical peptide synthesis has only limited abilities to synthesize long or complicated peptides whereas our proprietary recombinant peptide technology can handle the toughest possible peptide sequences of any length on any scale. Scalable System: In quantities of several milligrams up to 100... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
Our technical and applications support team can offer advice on library design and experimental set up and analysis. Relating to design we can advise on the best overlap or offset of peptides to be used in your target application and then using your full-length protein sequence we can generate the list of peptides for your library. Assistance with experimental set-up and analysis is available for applications such as ELISPOT cell culture intracellular cytokine staining and flow cytometry. The CreativePepTM Peptide Library technology can be used for a number of different types of library: • Overlapping peptide library • Alanine Scanning... read more
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Our technical and applications support team can offer advice on library design and experimental set up and analysis. Relating to design we can advise on the best overlap or offset of peptides to be used in your target application and then using your full-length protein sequence we can generate the list of peptides for your library. Assistance with experimental set-up and analysis is available for applications such as ELISPOT cell culture intracellular cytokine staining and flow cytometry. The CreativePepTM Peptide Library technology can be used for a number of different types of library: • Overlapping peptide library • Alanine Scanning... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
The recognition by Hofmeister and Emil Fischer that the structure of proteins is best represented by chains of amino-acids linked to each other through amide bond was preceded by the syntheses of the first simple peptide derivatives by Curtius and later by Fischer. With the discovery of biologically active peptides the objectives of synthesis underwent a dramatic change. As the pharmaceutical industry develops rapidly peptide synthesis becomes more widespread. Why Choose Creative Peptides? We can assist customers in selecting the appropriate peptide sequence purity and quantity suitable for your needs. Each step of peptide synthesis is subject to Creative Peptides'... read more
The recognition by Hofmeister and Emil Fischer that the structure of proteins is best represented by chains of amino-acids linked to each other through amide bond was preceded by the syntheses of the first simple peptide derivatives by Curtius and later by Fischer. With the discovery of biologically active peptides the objectives of synthesis underwent a dramatic change. As the pharmaceutical industry develops rapidly peptide synthesis becomes more widespread. Why Choose Creative Peptides? We can assist customers in selecting the appropriate peptide sequence purity and quantity suitable for your needs. Each step of peptide synthesis is subject to Creative Peptides'... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Creative Peptides has launched a series of MHC-peptide Tetramers which are ready-to-use reagents conjugated to a fluorochrome group such as Brilliant Violet 421(BV421) phycoerythrin (PE) or allophycocyanin (APC). In 1996 the development of reagents consisting of soluble MHC class I–peptide complexes which was applied to detect CD8+ cells by flow cytometry had effectively promoted a revolution of antigen-specific T cells. Traditionally TCR (T cell receptor) has a low avidity and fast off-rate for MHC-peptides complexes recombinant soluble monomeric MHC-peptide complexes have not been used to detect antigen-specific T cells. Recently Stanford University School of Medicine has presented MHC-peptides tetrameric complexes... read more
Creative Peptides has launched a series of MHC-peptide Tetramers which are ready-to-use reagents conjugated to a fluorochrome group such as Brilliant Violet 421(BV421) phycoerythrin (PE) or allophycocyanin (APC). In 1996 the development of reagents consisting of soluble MHC class I–peptide complexes which was applied to detect CD8+ cells by flow cytometry had effectively promoted a revolution of antigen-specific T cells. Traditionally TCR (T cell receptor) has a low avidity and fast off-rate for MHC-peptides complexes recombinant soluble monomeric MHC-peptide complexes have not been used to detect antigen-specific T cells. Recently Stanford University School of Medicine has presented MHC-peptides tetrameric complexes... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Therapeutic peptides and proteins as HIV-1 inhibitors have many advantages such as high specificity and affinity to their molecular targets and HIV-1 mutants are difficult to avoid these molecules and are gradually becoming an alternative strategy for HIV-1 therapy. The concept of targeting peptides to membranes to increase receptor interactions has been long known to peptide chemists. These peptides seem to work through different mechanisms and can prevent viruses from entering in a variety of ways. As an additional advantage such anti-HIV peptides may have other desired functions such as antibacterial anti-parasite spermicidal and anticancer activities. With the continuous optimization... read more
Therapeutic peptides and proteins as HIV-1 inhibitors have many advantages such as high specificity and affinity to their molecular targets and HIV-1 mutants are difficult to avoid these molecules and are gradually becoming an alternative strategy for HIV-1 therapy. The concept of targeting peptides to membranes to increase receptor interactions has been long known to peptide chemists. These peptides seem to work through different mechanisms and can prevent viruses from entering in a variety of ways. As an additional advantage such anti-HIV peptides may have other desired functions such as antibacterial anti-parasite spermicidal and anticancer activities. With the continuous optimization... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
The posttranslational modification of eukaryotic proteins by the addition of isoprenyl lipids at their C-termimi was first observed in the 1970s and 1980s. Since then more than a hundred proteins have been shown to be modified by C15 farnesyl or C20 geranylgeranyl groups including most members of the Ras Rho and Rab familied of G proteins. The C-terminal of the peptide is synthesized as an amide to neutralize negative charge created by the C-terminal COOH. This modification is added to prevent enzyme degradation to mimic native proteins and in some cases to remove hydrogen bonding at the C-terminal of the... read more
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The posttranslational modification of eukaryotic proteins by the addition of isoprenyl lipids at their C-termimi was first observed in the 1970s and 1980s. Since then more than a hundred proteins have been shown to be modified by C15 farnesyl or C20 geranylgeranyl groups including most members of the Ras Rho and Rab familied of G proteins. The C-terminal of the peptide is synthesized as an amide to neutralize negative charge created by the C-terminal COOH. This modification is added to prevent enzyme degradation to mimic native proteins and in some cases to remove hydrogen bonding at the C-terminal of the... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 631 619 7922
Copper peptide GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. The tripeptide has strong affinity for copper(II) and was first isolated from human plasma. It can be found also in saliva and urine.... read more
Tel: 631 619 7922
Copper peptide GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. The tripeptide has strong affinity for copper(II) and was first isolated from human plasma. It can be found also in saliva and urine.... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
Dipeptide-15 is the synthetic peptide consisting of glycine.... read more
Tel:
Dipeptide-15 is the synthetic peptide consisting of glycine.... read more
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