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7,171 RESULTS WITHIN anywhere FROM https:, United States
Distance: 12,798.63km
111-17 Lefferts Blvd South Ozone Park, Jamaica
Tel: 718-480-1212
Tej Bhulai CEO of Save Money On Glasses and author of “On Seeing Clearly †is a Board Certified Optician and Dispenser. He has more than a decade of experience working in well-known optical stores as an optician having cross-trained in both lab and retail venues. “After working behind the scenes for so many high-profile retailers I knew I could offer more value to clients saving them money and preserving quality of vision by helping them understand their prescriptions and make wise optical choices. “Customers understand unbeatable prices. Now I can help them understand more about their vision and how... read more
Tel: 718-480-1212
Tej Bhulai CEO of Save Money On Glasses and author of “On Seeing Clearly †is a Board Certified Optician and Dispenser. He has more than a decade of experience working in well-known optical stores as an optician having cross-trained in both lab and retail venues. “After working behind the scenes for so many high-profile retailers I knew I could offer more value to clients saving them money and preserving quality of vision by helping them understand their prescriptions and make wise optical choices. “Customers understand unbeatable prices. Now I can help them understand more about their vision and how... read more
Distance: 12,798.63km
575 Lexington Avenue Fourth Floor,New York, NY 10022, New York
Tel: 2129719773
The NY employment lawyers law - To speak with a top New York employment law attorney contact (212) 971-9773 now YOUNG And MA LLP. For a free consultation.Visit http://www.youngandma.com/... read more
Tel: 2129719773
The NY employment lawyers law - To speak with a top New York employment law attorney contact (212) 971-9773 now YOUNG And MA LLP. For a free consultation.Visit http://www.youngandma.com/... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
XL147 - CAS 956958-53-5 Catalog number: B0084-258924 Category: Inhibitor Not Intended for Therapeutic Use. For research use only. Molecular Formula C21H16N6O2S2 Molecular Weight 448.52 COA Inquire Targets PI3K Description Pilaralisib is a Class 1 phosphatidylinositol 3 kinase (PI3K) family inhibitor. It is an orally bioavailable small molecule targeting the class I PI3K family of lipid kinases. It is a pyrimidine derivatives compound discovered by Exelixis Inc. It has potential antineoplastic activity. It binds to class 1 PI3Ks in an ATP-competitive manner by inhibiting the production of the secondary messenger phosphatidylinositol-3 4 5-trisphosphate (PIP3) and inhibiting the activation of the PI3K... read more
XL147 - CAS 956958-53-5 Catalog number: B0084-258924 Category: Inhibitor Not Intended for Therapeutic Use. For research use only. Molecular Formula C21H16N6O2S2 Molecular Weight 448.52 COA Inquire Targets PI3K Description Pilaralisib is a Class 1 phosphatidylinositol 3 kinase (PI3K) family inhibitor. It is an orally bioavailable small molecule targeting the class I PI3K family of lipid kinases. It is a pyrimidine derivatives compound discovered by Exelixis Inc. It has potential antineoplastic activity. It binds to class 1 PI3Ks in an ATP-competitive manner by inhibiting the production of the secondary messenger phosphatidylinositol-3 4 5-trisphosphate (PIP3) and inhibiting the activation of the PI3K... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
Duvelisib also known as IPI-145 and INK-1197 is an orally bioavailable highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms PI3K signaling in normal non-neoplastic cells is minimally or... read more
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Duvelisib also known as IPI-145 and INK-1197 is an orally bioavailable highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms PI3K signaling in normal non-neoplastic cells is minimally or... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
The Hedgehog (Hh) gene was discovered in 1980 by Nusslein Volhard and Wieschaus for genetic analysis of Drosophila melanogaster. In the early 1990s three Hh homologous genes were found in vertebrates namely Sonic hedgehog (Shh) Indian hedgehog (Ihh) and Desert hedgehog (Dhh). Dhh and Ihh play important roles in the development of normal tissues such as pancreas testicular formation and bone development. Shh is the most important member of the three and is widely expressed in adult organizations. The Hh signaling pathway is a highly compliant signaling pathway that plays an important role in many aspects. Especially it plays a... read more
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The Hedgehog (Hh) gene was discovered in 1980 by Nusslein Volhard and Wieschaus for genetic analysis of Drosophila melanogaster. In the early 1990s three Hh homologous genes were found in vertebrates namely Sonic hedgehog (Shh) Indian hedgehog (Ihh) and Desert hedgehog (Dhh). Dhh and Ihh play important roles in the development of normal tissues such as pancreas testicular formation and bone development. Shh is the most important member of the three and is widely expressed in adult organizations. The Hh signaling pathway is a highly compliant signaling pathway that plays an important role in many aspects. Especially it plays a... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
RO4929097 a small-molecule inhibitor of γ secretase (IC50= 4 nM EC50= 5 nM) inhibits cellular processing of Aβ40 (EC50= 14 nM) and Notch(EC50= 5 nM). In vitro: Decreases the amount of Aβ peptides secreted into the culture medium in HEK293 cells (EC50= 14 nM); Strongly inhibits Notch processing (EC50= 5 nM) in the Notch cell-based reporter assay In vivo: Oral injection of 3 to 60 mg/kg RO4929097 once daily or twice daily to nude mice bearing A549 NSCLC xenografts for either 7 14 or 21 days of a 21-day schedule results in significant tumor growth inhibition compared with vehicle-treated animals.... read more
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RO4929097 a small-molecule inhibitor of γ secretase (IC50= 4 nM EC50= 5 nM) inhibits cellular processing of Aβ40 (EC50= 14 nM) and Notch(EC50= 5 nM). In vitro: Decreases the amount of Aβ peptides secreted into the culture medium in HEK293 cells (EC50= 14 nM); Strongly inhibits Notch processing (EC50= 5 nM) in the Notch cell-based reporter assay In vivo: Oral injection of 3 to 60 mg/kg RO4929097 once daily or twice daily to nude mice bearing A549 NSCLC xenografts for either 7 14 or 21 days of a 21-day schedule results in significant tumor growth inhibition compared with vehicle-treated animals.... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
MCC950 also called as CP-456773 or CRID3 is a small molecule that selectively inhibits activation of NLRP3 but does not inhibit NLRC4 AIM2 TLR2 signaling or priming of NLRP3. MCC950 can be used to treat inflammatory diseases. Molecular Formula C20H24N2O5S Molecular Weight 404.48 COA Inquire Targets NOD-like Receptors (NLRs)... read more
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MCC950 also called as CP-456773 or CRID3 is a small molecule that selectively inhibits activation of NLRP3 but does not inhibit NLRC4 AIM2 TLR2 signaling or priming of NLRP3. MCC950 can be used to treat inflammatory diseases. Molecular Formula C20H24N2O5S Molecular Weight 404.48 COA Inquire Targets NOD-like Receptors (NLRs)... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
PD-L1 checkpoint is operative in peripheral tissues and serves as a negative regulator of T-cells to help control local inflammatory responses and maintain self-tolerance. It is constitutively expressed on a subset of macrophages but may be rapidly upregulated in a number of different tissue types and by tumors in response to interferon-gamma and other inflammatory mediators. Many tumor cells constitutively express or are induced by interferon-γ (IFNγ) to express the inhibitory molecule PDL1. Additionally loss of the tumor suppressor gene phosphatase and tensin homolog (PTEN) increases tumor cell expression of PDL1. PDL1 was the third member of the B7 family... read more
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PD-L1 checkpoint is operative in peripheral tissues and serves as a negative regulator of T-cells to help control local inflammatory responses and maintain self-tolerance. It is constitutively expressed on a subset of macrophages but may be rapidly upregulated in a number of different tissue types and by tumors in response to interferon-gamma and other inflammatory mediators. Many tumor cells constitutively express or are induced by interferon-γ (IFNγ) to express the inhibitory molecule PDL1. Additionally loss of the tumor suppressor gene phosphatase and tensin homolog (PTEN) increases tumor cell expression of PDL1. PDL1 was the third member of the B7 family... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
BOC Sciences provides customers with top quality carbohydrates nucleosides and nucleotides. Our products range includes monosaccharides oligosaccharides nucleosides nucleotides and their modified analogs. Carbohydrates are the primary class for the biopolymers and present the greatest structural diversity of the biopolymers. Earlier the name "carbohydrate" was initially used to describe compounds that were literally "hydrates of carbon" because they usually had the empirical formula Cm(H2O)n in another word with a hydrogen–oxygen atom ratio of 2:1 (as in water). In recent years carbohydrates have been classified according to the degree of polymerization and the characteristics of the majority of carbohydrates found in... read more
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BOC Sciences provides customers with top quality carbohydrates nucleosides and nucleotides. Our products range includes monosaccharides oligosaccharides nucleosides nucleotides and their modified analogs. Carbohydrates are the primary class for the biopolymers and present the greatest structural diversity of the biopolymers. Earlier the name "carbohydrate" was initially used to describe compounds that were literally "hydrates of carbon" because they usually had the empirical formula Cm(H2O)n in another word with a hydrogen–oxygen atom ratio of 2:1 (as in water). In recent years carbohydrates have been classified according to the degree of polymerization and the characteristics of the majority of carbohydrates found in... read more
Distance: 12,798.63km
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
Peptide drug refers to a peptide having a specific therapeutic effect extracted by chemical synthesis genetic recombination or animal or plant and is a specific application of the peptide in the field of medicine. The biological activity of the peptide is extensive and important and it can be widely applied to the endocrine system the immune system the digestive system the cardiovascular system the blood system the musculoskeletal system etc.... read more
Tel:
Peptide drug refers to a peptide having a specific therapeutic effect extracted by chemical synthesis genetic recombination or animal or plant and is a specific application of the peptide in the field of medicine. The biological activity of the peptide is extensive and important and it can be widely applied to the endocrine system the immune system the digestive system the cardiovascular system the blood system the musculoskeletal system etc.... read more
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